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Course Evaluations
End-of-course evaluations for all basic science courses offered by the Duke School of Medicine will soon be administered via an online portal. Stay tuned for details.
End-of-course evaluations for all basic science courses offered by the Duke School of Medicine will soon be administered via an online portal. Stay tuned for details.
2010 Spring Courses Master Listing
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BIOCHEM/SBB 222 - Structure Bio Macromol
(Th 1:15–3:15 pm, 439 Nanaline Duke Bldg.; Richardson; 3 units) Macromolecular structures by interactive 3D graphics: examples, principles, and techniques for analysis, emphasizing the patterns and determinants of protein and RNA structure. Two-hour discussion session each week along with computer-based lessons and individual projects. Instructors: D. Richardson and J. Richardson (Course ID #001397)
BIOCHEM 228 - Introduction to Biochemistry II
(MWF 10:20–11:10 am & recitations on M or T 4 pm, 147 Nanaline Duke Bldg.; Been/Staff; 3 units) Structure, biosynthesis and function of important membrane lipids, membrane proteins and membrane-associated carbohydrates. Carbon and nitrogen fixation and assimilation, and the synthesis of amino acids and nucleotides. Current topics in chromatin structure and dynamics, RNA processing and gene expression. (Course ID #001400)
BIOCHEM/SBB 291 - Physical Biochemistry
(MWF 3:05–3:55 pm, 147 Nanaline Duke Bldg.; Oas/Staff; 3 units) Basic principles of physical chemistry as applied to biological systems. Topics include thermodynamics, kinetics, statistical mechanics, spectroscopy, and diffraction theory. Concepts discussed in the context of the biochemistry and behavior of biological macromolecules. Emphasis on quantitative understanding of biochemical phenomena, with extensive problem solving as an instructive tool. Prerequisite: undergraduate physical chemistry and one year of calculus. Instructor: Oas and staff (Course ID #001410)
BIOCHEM/CBI/MCB/PHARM 417 - Cellular Signaling
(MWF 8:45-9:35 am, 147 Nanaline Duke Bldg.; Caron; 3 units) Mechanism of action of hormones at the cellular level including hormone-receptor interactions, secondary messenger systems for hormones, mechanisms of regulation of hormone responsiveness, regulation of growth, differentiation, proliferation and apoptosis, mechanisms of transport and ion channels, stimulus sensing and transduction. Some lectures stress cellular signaling in integrated systems as well as the clinical correlation of the basic course concepts. Instructor: Caron, Pendergast, York, Means, Kornbluth and invited lecturers. (Course ID #002090) CBI 203 - Introduction to Physiology
(MWF 8:45-9:35 am, 143 Jones Bldg.; Jakoi/Wright; 2 units, first half-semester) The objective of the course is to provide an introduction to Human Physiology with information about how the basic organ systems (lung, cardiovascular, gastrointestinal, endocrine, and kidney) of the body work and how the systems are coordinated. (Course ID #002041)
CBI 206 - Physiology and Medicine of Extreme Environments
(MW 5:00-6:30 pm, CR-2, Room 0585, Basement, Duke South; Vann/Freiberger; 3 units, Enrollment: max 2) Advanced topics in the physiology and medicine of ambient pressure, immersion, gravity, temperature, and gas composition. Environments considered include: diving and hyperbaric medicine; hot/cold terrestrial and water operations; microgravity and high-g acceleration; high altitude: and space. Basic mechanisms and medical management of: decompression sickness; altitude sickness; hypothermia and hyperthermia; hypoxia; carbon monoxide poisoning; and oxygen toxicity. Practical applications: pressure vessel design and operation; life support equipment; cardiorespiratory physiology measurements at low and high pressure; simulated dive and flight (optional). Prerequisites: Physics, human anatomy and physiology, permission of the course director (contact Dr. Vann at 684-3305 or rvann@dan.org). Cross listed with ANESTH445. (Course ID # 011631)
CBI/MCB 208 - Stem Cell and Developmental Biology
(T-Th 10:05–11:20 am, 384 Nanaline Duke Bldg.; Reya/Hogan; 3 units, full semester) Lecture/discussion format designed for first-year graduate students to learn the fundamentals of stem cell biology and to gain familiarity with current research in the field. Prerequisites: undergraduate level cell biology, molecular biology, and genetics. (Course ID #015228)
CBI 243 - Respiartoy Proteins and the Environment
(Beaufort Marine Lab Course, Block C; Bonaventura) Structure, function and evolution of copper and iron based respiratory proteins in response to environmental oxygen levels and physiological needs. Lectures and readings on balance between pathways for metabolic oxygen utilization and alternative disease-causing pathways involving oxidative and nitrosative reactions. Interactive molecular graphics aand student presentations supplement text and lectures. Covers molecular adaptations, circulation, allostery, reaction kinetics and thermodynamics. Reactive oxygen and nitrogen species, gene expression, blood pathogens, malaria, sickle cell anemia. (Prerequisites: organic chemistry or consent of instructor).
CBI 280 – Seminar
(M 4:25–5:25 pm, Location TBA; Capel; 1 unit) Preparation and presentation of seminars to students and faculty based on current papers covering topics of broad interest to cell biology and physiology. Required of Department of Cell Biology students. (Course ID #002074)
CBI 296 - Developmental Biology Colloquium
(M 5:00–6:00 pm, 384 Nananline Duke Bldg.; W 4:00–6:00 pm, 147 Nanaline Duke Bldg.; Sherwood; 3 units) This course covers a broad range of problems in developmental biology based on prominent developmental biologists who are invited to speak at Duke University during that particular semester and participate in discussions with the class. (Course ID #002078)
CBI/BIOCHEM/MCB/PHRM 417 - Cellular Signaling
(MWF 8:45–9:35 am, 147 Nanaline Duke Bldg.; Caron; 3 units) Mechanisms of signaling at the cellular level, including ligand/receptor interactions and secondary messenger systems. Some lectures stress the clinical correlation of the basic course concepts. (Course ID # 002090)CMB 264 - Student Seminar
(M 11:50-1:00 pm, 143 Jones Bldg.; Kuehn; 2 units) Required of all CMB students. Presentations by upper-year students: one student talks about ongoing dissertation research and another introduces a research paper relevant to that week's seminar. Students attend the Thursday seminar (Cell Structure and Function) and can have lunch with the speaker. (Course ID #002534)
CBB 210 - Computational Biology Seminar
(M 11:00 am–12:00 pm, 4233 French; Harer; 1 unit) A weekly series of seminars on topics in computational biology presented by invited speakers, Duke faculty and CBB doctoral and certificate graduate students. (Course ID #014567)
CBB 211 - Journal Club/Research in Progress
(W 10:20–11:10am, 100 North; Furey; 1 unit) A weekly series of discussions led by students that focus on current topics in computational biology. Topics of discussion may come from recent or seminal publications in computational biology or from research interests currently being pursued by students. First and second year CBB doctoral and certificate students are strongly encouraged to attend as well as any student interested in learning more about the new field of computational biology. (Course ID # not on template)
CBB 212 - Responsible Genomics
(T 4:25–6:55 pm, Location TBD; Cook-Deegan; 3 units) This course will introduce students to issues that arise in doing, interpreting, or applying genomics research. It includes (1) introduction to ethical reasoning and examination of selected issues calling for such analysis, including potential for conflicts among roles that an individual is expected to fulfill; (2) skills needed in any subsequent career path that involves doing or bioinformatics or genomics research, including research or professional school; doing presentations, writing a policy memo, and working in a group; (3) understanding why there are special procedures for research involving human participants, and how to respect privacy and confidentiality of genetic information; (4) historical and political background on sources of health research funding, and (5) issues involving public–private research interactions such as intellectual property and conflict of interest.
CBB 240 - Statistical Methods for Computational Biology
(MW 1:15–2:30 pm, Location TBD; Mukherjee; 3 units) Methods of statistical inference and stochastic modeling with application to functional genomics and computational molecular biology. Topics include: statistical theory underlying sequence analysis and database searching; Markov models; elements of Bayesian and likelihood inference; multivariate high-dimensional regression models, applied linear regression analysis; discrete data models; multivariate data decomposition methods (PCA, clustering, multi-dimensional scaling); software tools for statistical computing. Prerequisites: multivariate calculus, linear algebra and Statistics 213. C-L: Statistics and Decision Sciences 270 (Course ID #015067)
CBB 261 - Computational Sequence Biology
(MW 4:25–5:40 pm, 225 North Bldg.; Ohler; 3 units) Introduction to algorithmic and computation issues in analysis of biological sequences: DNA, RNA and protein. Emphasizes probabilistic approaches and machine learning methods, e.g. Hidden Markov models. Explores applications in genome sequence assembly, protein and DNA homology detection, gene and promoter finding, motif identification, models of regulatory regions, comparative genomics and phylogenetics, RNA structure prediction, post-transcriptional regulation. Prerequisites: basic knowledge algorithmic design (Computer Science 230 or equivalent), probability and statics (Statistics 213 or equivalent), molecular biology (Biology 118 or equivalent). One course. C-L: Computational Biology and Bioinformatics 261ENV 240 - Chemical Fate of organic Compounds
(TTh 4:25-5:40 pm, A247 LSRC; Stapleton; 3 units) Equilibrium, kinetic, and analytical approaches applied to quantitative description of processes affecting the distribution and fate of anthropogenic and natural organic compounds in surface and groundwaters, including chemical transfers between air, water, soils/sediment, and biota; and thermochemical and photochemical transformations. (Course ID # Not on Template)
ENV/PHRM 315 - Focused Topics in Toxicology
(M 8:45-11:00 am, A312 LSRC; Levin; 1 unit) A contemporary advanced toxicology research area will be covered with readings from the current primary literature. An integrative review of the topic will be prepared as a collaborative effort. Prerequisites: Consent of instructor required. Pharmacology 233, Pharmacology 347. (Course ID #004217)
ENV/PHRM 348 - Seminar in Toxicology
(F 1:15–2:30 pm, A247 LSRC; Levin; 1 unit) Research seminar series takes place on Friday afternoons throughout the year - students, faculty and invited speakers make weekly presentations of research findings. In addition, faculty and trainees attend two symposia each year as a means of enhancing interaction among those involved in the Program. These are one-day topical symposia with seminars from Duke faculty and internationally respected toxicologists. After presentations of research findings, students prepare short papers concerning each seminar and symposium topic. (Course ID #007812)
IMM 202 - Laboratory Rotations
(Staff; 1 unit) Laboratory rotation for first year Immunology graduate students, second semester. (Course ID #018444)
IMM 291 - Comprehensive Immunology
(MWF 10:20–11:10 am, 465 Sands; Zhuang; 3 units) In depth coverage and analysis of the immune system. Major topics include: lymphocyte development; generation of antigen receptors; lymphocyte activation and signaling; effector functions; memory development and maintenance; immune tolerance; antigen presentation and dendritic cells; neonatal immunity; mucosal immunity. Reading of assigned literatures is required prior to attending each lecture. Pre-requisition: Imm244 or equivalent course. ((Course ID # 005693)
IMM 310 – Immunopathogenesis
(TTH 10:05–11:20 am, 415 Jones; St. Clair/Kelsoe; 3 units) A course designed to appeal to graduate students, medical students, and clinical and post-doctoral fellows. Lectures are structured to include sufficient introductory material to ensure understanding by all trainees but are advanced with respect to the interface of basic and clinical immunology. A text (Abbas et al.) and primary literature sources will supplement the lecture materials. Final grades will be determined on the basis of mid-term and final examinations. Course objectives include understanding of immune-mediated pathogenesis in human disease, including auto-immunity, transplantation tolerance, allergy and asthma, atherosclerosis, and immuno-deficiency diseases. These topics are considered with respect to the molecular- and cellular mechanisms of immune-associated disease. (Course ID # Not on Template)
IMM 331 – Seminar
(M 4:00-5:00 pm, 001 MSRB; Kondo; 1 unit) Required course for all students specializing in immunology. First and Second year students should sign up for IMM 331 which is graded credit. Work in progress seminar in which students and postdoctoral trainees give 30 min -1 hour presentations of their research. Considered a showcase of current research in the Department of Immunology. All students enrolled in the Immunology program are required to give a presentation once per year. Informal questions and discussion are encouraged throughout presentation. (Course ID #017464)
IMM 332 – Seminar
(M 4:00-5:00 pm, 001 MSRB; Kondo; 1 unit) Required course for all students specializing in immunology. Third through Fifth Year Students and non-Immunology majors should sign up for IMM332 which is credit/noncredit. Work in progress seminar in which students and postdoctoral trainees give 30 min -1 hour presentations of their research. Considered a showcase of current research in the Department of Immunology. All students enrolled in the Immunology program are required to give a presentation once per year. Informal questions and discussion are encouraged throughout presentation. (Course ID # 005699)
IMM 336 - Topics in Immunology
(Th 8:45-10:00 am, 147 Nanaline; Kondo; 1 unit) Focus on current immunology research, emphasizing emerging research areas and new directions in established areas. Students present recent papers in selected subjects. (Course ID #005701)MEDPHY 210 - Radiation protection
(TTh 11:40 am–12:55 pm, 1032 Hock; Yoshizumi; 3 units) Course discusses the principles of radiation protection dealing with major forms of ionizing and non-ionizing radiation, the physics and chemistry of radiation biology, biological effects of ionizing and non-ionizing radiations (lasers, etc.) at cellular and tissue levels, radiation protection quantities and units, medical HP issues in clinical environments, radiation safety regulations, and basic problem solving in radiation safety.
MEDPHY 220 - Radiation therapy physics
(TTh 10:05–11:20 am, 1032 Hock; Oldham; 3 units) This introductory course has a clinical orientation, and reviews the rationale, basic science, methods, instrumentation techniques and applications of radiation therapy to the treatment of a wide range of human diseases. Major radiation modalities are covered including low and high energy photon therapy, electron and proton therapy, and low and high-dose rate brachytherapy. The clinical process of treatment, methods of calculating dose to patient, and the role of the medical physicist in radiation oncology clinic, are covered in detail.
MEDPHY 241 - Nuclear medicine physics
(TTh 8:30–9:45 am, 1032 Hock; Turkington; 3 units) Topics include basics of nuclear medicine imaging, gas, scintillation, and solid state radiation detectors, counting statistics, gamma camera principles including modern digital designs, SPECT, coincidence imaging principles, PET instrumentation, radionuclide and x-ray CT transmission scanning techniques, nuclear medicine treatments, and surgical probes.
MEDPHY 251 - Medical physics seminar
(Th, 2:50–4:15 pm, Hock Auditorium; 1 unit) Weekly seminar on various topics pertaining to medical physics.
MEDPHY 323 - Advanced brachytherapy and special procedures
(MW 8:30–9:45 am, South H.; Yinl; 1-3 units) This course will cover advanced LDR and HDR brachytherapy, and other, selected special procedures and special topics. Prerequisite: MP 220.
MEDPHY 326 - Monte Carlo methods in medical physics
(T 1:15–4:05 pm, Rad Safety; Gunasingha; 1-3 units) Provide an introduction to the use of the Monte Carlo method in radiation transport. The acquired knowledge will be applicable to dosimetry problems, detector simulations or shielding calculations. Demonstrate setup and solutions of sample problems using MCNP or other MC codes.
MEDPHY 327 - Observership in clinical radiation oncology
(MTTh 8:30 am–4:30 pm, South H.; Kirkpatrick; 1 unit) The course aims to provide an appreciation for the practical procedures, realities, and workflow that pertains the clinical practice of radiation oncology. Though a shadowing arrangement, the students will be directed by a clinical oncologist to experience the decision making processes, the interface with various member of the treatment team, the treatment planning, and the interface with the physics staff. Pre-requisite: MP 220 and MP 322 (or MP 322 concurrently)
MEDPHY 328 - Clinical practicum and shadowing (Radiation Therapy)
(W 5:00-8:00 pm, South H.; Wang/Wu; 3 units) The course gives hands on experience in practical aspects of medical physics as applied to radiation therapy. Special emphasis is given to the operation of various therapy units and dose measuring devices, techniques of measuring the characteristics of radiation beams, commissioning and quality assurance checks for radiation producing devices in the clinic. The course includes shadowing a clinician, technologist, or physicist, while performing their routine clinical tasks.
MEDPHY 339 - Clinical practicum and shadowing (Diagnostic Imaging)
(MW 1:15–2:30 pm, RAI Labs; Samei; 3 units) Review and real-life exercises on principles of modern medical imaging systems with emphasis on the engineering and medical physics aspects of image acquisition, reconstruction and visualization, observations of imaging procedures in near clinical settings, and hands-on experience with the instruments. Modalities covered include ultrasound, CT, MRI, nuclear medicine and optical imaging. Medical Physics students will substitute X-ray imaging for the Nuclear imaging module. Prerequisite: BME 233/MP230 or equivalent.
MEDPHY 359 - Independent study
An independent research project with a faculty advisor.
MEDPHY 370 - Frontiers of Biomedical Sciences
(MW 10:05–11:20 am, 1032 Hock; Wong; 3 units) A course covering the frontier topics of biomedical sciences that are currently not within the domain of medical physics, but medical physicists, nonetheless, need to have knowledge of. Topics include genomics, bioinformatics, proteomics, and others.
Molecular Genetics & Microbiology
MGM 203 - Independent Study
(Staff)
MGM/UPGEN 222 - Critical reading in genetics
(T-Th 4:25-5:40 pm, 408 CARL; Heitman; 3 units) The primary objective of this course is to develop critical analysis and creative thinking skills, especially with regard to reading and assessing the published literature. In particular, we hope that students taking the course will be readily able to assess the validity of the claims in a paper, and to design experimental approaches that take off from the observations in the paper to address the next question. (Course ID #15229)
MGM 252 – Virology
(MWF 3:05–3:55 pm, 408 CARL; Cullen; 3 units) Molecular biology of mammalian viruses, with emphasis on mechanisms of replication, virus-host interactions, viral pathogenicity, and the relationship of virus infection to neoplasia. (Course ID #015230)
MGM 282 - Microbial Pathogenesis
(MWF 1:30–2:20 pm, Location TBA; McCusker; 3 units) Modern molecular genetic approaches to understanding the pathogenic bacteria and fungi. Underlying mechanisms of pathogenesis and host- parasite relationships that contribute to the infectious disease process. (Course ID #015233)
MGM 301 - Topics in Molecular Genetics & Microbiology
(F 4:00-5:00 pm, 001 MSRB; Valdivia; 2 units) This is a student seminar with two students presenting each seminar. Refreshments are provided by first year students. (Course ID #015235)
MGM 302 - Scientific Writing
(M-W 8:45-9:30 am, 001 MSRB; Staff; 2 units) Introduction to grant and fellowship writing; writing assignment of two proposal topics; evaluation and critique of proposal by fellow students. (Same class content as UPGEN 306 Writing Grant Proposals) (Course ID # 017624)MCB/CBI 208 - Stem Cell Biology
(T-Th 10:05–11:20 am, 384 Nanaline Duke; Reya; 2 units, first half semester) The course is designed for first-year graduate students to learn the fundamentals of stem cell biology and to gain familiarity with current research in the field. The course will be presented in a lecture and discussion format based on the primary literature. Topics include: stem cell concepts, methodologies for stem cell research, embryonic stem cells, adult stem cells, cloning and stem cell reprogramming and clinical applications of stem cell research. Prerequisites: undergraduate level cell biology, molecular biology, and genetics. (Course ID #015228)
MCB 300 - Cancer as a Disease
(M 1:15–2:30 pm, C335 LSRC; Wechsler-Reya; 2 units) This course looks at cancer from the point of view of the patient, the doctor and the scientist. Faculty from around the medical center will discuss diagnosis, detection and prediction of cancer, the molecular basis of the disease, and new approaches to therapy. The object is to give students a deeper appreciation for the clinical aspects of cancer and how molecular biology can contribute to improved understanding and treatment of the disease. This course is mandatory for all MCB students, and would be suitable for second year students with a solid background in molecular biology. Permission is required to participate, class limit is 15. (Course ID # 006505)
MCB/PHRM 280 - Student Seminar
(Th 4:15–5:30 pm, C144 LSRC; Thiele, Wang/Yao; 2 units) Preparation and presentation of seminars to students and faculty on topics of broad interest to Cancer Biology and Pharmacology. Required of all MCB students. (Course ID #012582)
MCB/CBI/BIOCHEM/PHRM 417 - Cellular Signaling
(MWF 8:45–9:35 am, 147 Nanaline Duke Bldg.; Caron; 3 units) Mechanism of action of hormones at the cellular level including hormone-receptor interactions, secondary messenger systems for hormones, mechanisms of regulation of hormone responsiveness, regulation of growth, differentiation, proliferation and apoptosis, mechanisms of transport and ion channels, stimulus sensing and transduction. Some lectures stress cellular signaling in integrated systems as well as the clinical correlation of the basic course concepts. Instructor: Caron, Pendergast, York, Means, Kornbluth and invited lecturers. (Course ID #002090)
Neurobio 202 - Basic Neurobiology
(January, Location TBA; White; 4 units) A systematic introduction to the structure and function of the mammalian nervous system, offered in conjunction with first-year course for Medical students. Lectures, laboratory, exercises, clinical presentations, and problem-solving conferences during the month of January. Neurobiology students will participate in general sessions with Medical Students. Separate labs will be conducted specifically for Neurobiology Students. Permission of instructor required. (Course ID #007223)
Neurobio 212 - Research Independent Study
(TBA; Staff Instructor; 3 units) Individual research and reading of the primary literature in a field of special interest, under the supervision of a faculty member, the major product of which is a substantive paper or written report containing significant analysis and interpretation of a previously approved topic. Consent of instructor required. (Course ID #015262)
Neurobio 280 - Student Seminar
(F 11:55 am–1:00 pm, 101L Bryan Research Bldg.; Yasuda; 1 unit) Preparation and presentation of seminars to students and faculty on topics of broad interest in neurobiology. Course required of all first- and second-year neurobiology students. Consent of Instructor required. (Course ID # 007235)
Neurobio 320 - Concepts in Neuroscience II
(MW 9:00 am*–12:00 pm; 101L Bryan Research Bldg.; Mooney; 3 units) The principles of organization of neurons into functional circuits will be examined through a combination of lectures, readings, individual projects, and in-class discussions. Emphasis will be on the sensory and motor systems and their integration into a functional whole. Aspects of development of neuronal circuitry will also be addressed. Course required for first-year neurobiology students. Prerequisites: NBI 319, NBI 202. Consent of instructor required. (Course ID #018291)
Neurobio 326 - Neurobiology Journal Club
(T 11:55 am–2:30 pm, F 4:00 pm–5:00 pm, Bryan Research Bldg.; West; 1 unit) Once a month, first and second year neurobiology graduate students meet to hold a student-run journal club to discuss the work of an invited seminar speaker from an outside institution. On the following Tuesday, the students attend the seminar, then have lunch with the speaker. Consent of Instructor required. (Course ID #018923)
Neurobio/PHM 333 - Statistics for Basic Biomedical Scientsts
(section 01: T 8:30–10:15 am, C144 LSRC; Slotkin; 2 units) (section 02: W 8:30–10:15 am, C144 LSRC; Slotkin; 2 units) The use and importance of statistical methods in laboratory science, with an emphasis on the ‘nuts and bolts” of experimental design, hypothesis testing, and statistical inference. Central tendency and dispersion, Gaussian and Non-Gaussian distribution, parametric and non-parametric tests, uni- and multivariate, ANOVA and regression procedures are covered. Students will present their own data and literature examples in addition to lectures. (Course ID #007809)
Neurobio/PSYCH/PHIL 350S - Principles in Cog Neuro II
(MW 1:15–2:30 pm, B240 LSRC; Cabeza; 3 units) Introduction to the cognitive neuroscience of emotion, social cognition, executive function, development, and consciousness. Topics also include cognitive disorders and computer modeling. Highlights current theories, methodological advances, and controversies. Students evaluate and synthesize findings across a variety of research techniques. Consent of instructor required. (Course ID # Not on Template)
Neurobio/PHR 364 – Neurotoxicology
(M 10:20–11:50 am, Location TBA; Abou-Donia; 3 units) Adverse effects of drugs and toxicants on the central and peripheral nervous system; target sites and pathophysiological aspects of neurotoxicity; factors affecting neurotoxicity, screening and assessment of neurotoxicity in humans; experimental methodology for detection and screening of chemicals for neurotoxicity. (Course ID #007816)
Neurobio 372 - Research in Neurobiology
(TBA; Staff Instructor; 1-16 units) Guided independent study and research experience in neurobiology. Nature of topic to be decided by individual arrangement with faculty advisor. Consent of faculty advisor required. (Course ID #007248)
PTH 250.01 - General Pathology
(MWF 3:05–4:30 pm, Room 409 Davison Bldg.; Hale; 4 units) Lectures deal with broad concepts of disease and underlying molecular mechanisms. Laboratory sessions familiarize the student with how to identify common disease processes in histologic sections. PTH 225 (histology) or an equivalent course is a prerequisite and consent of instructor is required. (Course ID #009154)
PTH 355 - Graduate Seminar in Pathology
(Th 4:00–5:00 pm, M224 Davison Bldg.; Abraham; 1 unit) Discussions outlining the scope of modern pathology. This will include reports of original research by graduate students, members of staff and visitors. (Course ID #009161)
PTH 385.01 - Molecular Aspects of Disease
(T-Th 10:05–11:30 am, M3114 Davison Bldg.; Yan/Datto; 3 units) This course is based upon the study of the background, investigative method and recent advances in understanding the molecular basis of selected diseases, with an in-depth focus on a small number of diseases where defects are known at genetic or molecular levels. (Course ID #009175)
PHR 234 - Interdisciplinary Approaches to Pharmacology
(MWF 3:05-3:55 pm, C144 LSRC; Rathmell/Wang/Whorton; 4 units) Several model systems (cancer, immunological, cardiovascular, reproductive, neurological and infective diseases) will be used to explore the molecular, biochemical, and physiologic basis of drug action. (Course ID # 007798)
PHR/MCB 280 – Seminar
(Th 4:10-5:10 pm, C144 LSRC; Thiele/Wang/Yao; 2 units) Preparation and presentation of seminars to students and faculty on topics of broad interest to pharmacology. Required of all pharmacology and MCB students. Crosslisted with MOLCAN 280. (Course ID #007802)
PHR 314 - Case Studies in Toxicology
(M 1:15–3:00 pm, C336 LSRC; Abou-Donia; 1 unit) Students are assigned topics relative to their chosen research discipline in toxicology and are asked to develop case studies to present at a roundtable workshop. Emphasis on review and analysis of toxicological problems from a holistic (multidisciplinary) viewpoint. Offered on demand. (Course ID #004216)
PHR/ENV 315 - Focused Topics in Toxicology
(M 8:45-11:00 am, A312 LSRC; Levin; 1 unit) A contemporary advanced toxicology research area will be covered with readings from the current primary literature. An integrative review of the topic will be prepared as a collaborative effort. Prerequisites: Consent of instructor required. Pharmacology 233, Pharmacology 347. (Course ID #004217)
PHR/NEUROBIO 333 - Statistics for Basic Biomedical Scientists
(section 01: T 8:30–10:15 am, C144 LSRC; Slotkin; 2 units) (section 02: W 8:30–10:15 am, C144 LSRC; Slotkin; 2 units) The use and importance of statistical methods in laboratory science, with an emphasis on the ‘nuts and bolts” of experimental design, hypothesis testing, and statistical inference. Central tendency and dispersion, Gaussian and Non-Gaussian distribution, parametric and non-parametric tests, uni- and multivariate, ANOVA and regression procedures are covered. Students will present their own data and literature examples in addition to lectures. Consent of Instructor required. (Course ID# 007809)
PHR/ENV 348 - Seminar in Toxicology
(F 1:15–2:30 pm, A247 LSRC; Levin; 1 unit) Research seminar series takes place on Friday afternoons throughout the year - students, faculty and invited speakers make weekly presentations of research findings. In addition, faculty and trainees attend two symposia each year as a means of enhancing interaction among those involved in the Program. These are one-day topical symposia with seminars from Duke faculty and internationally respected toxicologists. After presentations of research findings, students prepare short papers concerning each seminar and symposium topic. (Course ID #007812)
PHR/NEUROBIO 364 – Neurotoxicology
(M 10:20–11:10 am, C144 LSRC; Abou-Donia; 3 units) Adverse effects of drugs and toxicants on the central and peripheral nervous system; target sites and pathophysiological aspects of neurotoxicity; factors affecting neurotoxicity, screening and assessment of neurotoxicity in humans; experimental methodology for detection and screening of chemicals for neurotoxicity (Course ID #007816)
PHR/BCH/CBI/MCB 417 - Cellular Signalling
(MWF 8:45-9:35 am, 147 Nanaline Duke Bldg.; Caron; 3 units) Mechanism of action of hormones at the cellular level including hormone-receptor interactions, secondary messenger systems for hormones, mechanisms of regulation of hormone responsiveness, regulation of growth, differentiation and proliferation, mechanisms of transport and ion channels, stimulus sensing and transduction. Some lectures stress the clinical correlation of the basic course concepts. Instructor: Caron, Means, and invited lecturers. (Course ID # 002090)
Structural Biology & Biophysics
SBB 345.01 - SBB Seminar
(M 4:00-5:00* pm, 437 Nanaline Duke Bldg.; Oas; 1 unit) Weekly seminars are presented by program students beyond their first year, faculty members or guest speakers. (Required of all SBB Students.) (*actual time) (Course ID # not on template)
SBB/BCH 222.01 - Structure Bio Macromol
(Th 1:15–3:15 pm, 439 Nanaline Duke Bldg.; Richardson; 3 units) Computer graphics intensive study of some of the biological macromolecules whose three-dimensional structures have been determined at high resolution. Emphasis on the patterns and determinants of protein structure. Two-hour discussion session each week along with computer-based lessons and projects. Instructors: D. Richardson and J. Richardson. (Course ID #001397)
SBB/BCH 291.01 - Physical Biochemistry
(MWF 3:05–3:55 pm; Oas/Staff; 3 units) Basic principles of physical chemistry as applied to biological systems. Topics include thermodynamics, kinetics, statistical mechanics, spectroscopy, and diffraction theory. Concepts discussed in the context of the biochemistry and behavior of biological macromolecules. Emphasis on quantitative understanding of biochemical phenomena, with extensive problem solving as an instructive tool. Prerequisite: undergraduate physical chemistry and one year of calculus. Instructor: Oas and staff. (Course ID #001410)
Univeristy Program in Genetics
UPGEN/MGM 222 - Critical Readings in Genomics and Genetics
(T-Th 4:10–5:30 pm, 408 CARL; Heitman; 4 units) The primary objective of this course is to develop critical analysis and creative thinking skills, especially with regard to reading and assessing the published literature. In particular, we hope that students taking the course will be readily able to assess the validity of the claims in a paper, and to design experimental approaches that take off from the observations in the paper to address the next question. (Cross referenced with MGM 222; Course ID #015230)
UPGEN 233 - Genetic Epidemiology
(T 8:30-9:45 am, 2029 GSRB II; Ashley-Koch/Staff; 3 units) This course will cover traditional genetic epidemiologic methods such as study design, linkage, analysis and genetic association. More recent methodology on analysis of whole genome association data, as well as gene*gene* environment interactions will also be discussed. (Course ID #018599)
UPGEN 287/BIO 187 - Evolutionary Genetics
(T-Th 2:50–4:05 pm, Room 130 Physics Bldg.; Noor; 3 units) An introduction to the principles of evolutionary genetics, with discussion of the current literature and hands-on exercises. Genetic variation, neutral theory, natural selection, human population genetics, phylogenetic reconstruction, evolutionary genomics and evolutionary bioinformatics. This course is paired with BIO 187. (Course ID #010286)
UPGEN 301 - Advanced Topics in Genetics and Genomics
(W 6:00-7:15 pm; Sullivan/Chi; 2 units) This course is only open to first year UPGG graduate students. It is a weekly discussion of current literature in genetics (Fall semester) and genomics (Spring semester). The course has two objectives. The first is to ground each of the members of the UPGG first year class, regardless of areas of interest, in the two areas of focus of the program – namely genetics and genomics. The second objective is to facilitate interactions among the diverse student body by bringing the class together once a week for discussion. (Course ID #0017195)
UPGEN 306.1 - Writing Grant Proposals
(M-W 8:45-9:30 am, 001 MSRB; Marchuk; 2 units) This course is for students interested in learning tools for writing grant proposals. (Same Class Content as MGM 302 Scientific Writing) (Course ID #018598)
UPGEN 316.01 - Student Research Seminar
(Every other Friday 4:00–5:00 pm, MSRB 001; 1 unit) This is a student seminar with two advanced students presenting each seminar. Refreshments are provided by first year students. (Course ID #010288)
UPGEN 350.01 - Genetics Colloquium/Tuesday Seminar Series
(T 12:30–1:30 pm, Room 147 Nanaline Duke Bldg.; Hosted by various faculty and student members) Sponsored by the UPGG and IGSP. (Course ID #010290)
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